Gene information
Official symbol CXCL10
Official full name C-X-C motif chemokine ligand 10
Gene type protein-coding gene
Chromosome4q21.1
Alias symbolIFI10; IP-10; crg-2; mob-1; C7; gIP-10
Previous symbolINP10; SCYB10
Gene familyChemokine ligands
Resources
Entrez Gene 3627
HGNC HGNC:10637
Ensembl ENSG00000169245
Vega OTTHUMG00000160887
UCSC uc003hjl.5
GO terms: 105 records
GO Description Category LogP Number of genes Detail
GO:0001664 G protein-coupled receptor binding GO Molecular Functions -22.7408810 35 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002687 positive regulation of leukocyte migration GO Biological Processes -31.0737422 33 More
GO:0002688 regulation of leukocyte chemotaxis GO Biological Processes -31.6279962 32 More
GO:0002690 positive regulation of leukocyte chemotaxis GO Biological Processes -28.1480961 27 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0006959 humoral immune response GO Biological Processes -20.5068158 33 More
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO Biological Processes -9.16710904 33 More
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO Biological Processes -6.95524830 22 More
GO:0007517 muscle organ development GO Biological Processes -15.8908392 49 More
GO:0007584 response to nutrient GO Biological Processes -29.4823239 48 More
GO:0008009 chemokine activity GO Molecular Functions -11.8970416 12 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008201 heparin binding GO Molecular Functions -33.5542939 37 More
GO:0009266 response to temperature stimulus GO Biological Processes -12.1149168 32 More
GO:0009314 response to radiation GO Biological Processes -9.77450393 26 More
GO:0009408 response to heat GO Biological Processes -9.27499209 13 More
GO:0009409 response to cold GO Biological Processes -5.06845562 11 More
GO:0009612 response to mechanical stimulus GO Biological Processes -18.7627330 44 More
GO:0009615 response to virus GO Biological Processes -11.2861143 47 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0016525 negative regulation of angiogenesis GO Biological Processes -31.9326641 51 More
GO:0019207 kinase regulator activity GO Molecular Functions -2.87704457 10 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0019730 antimicrobial humoral response GO Biological Processes -11.7829906 16 More
GO:0019887 protein kinase regulator activity GO Molecular Functions -2.69690139 9 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0030593 neutrophil chemotaxis GO Biological Processes -16.9449855 18 More
GO:0030595 leukocyte chemotaxis GO Biological Processes -30.6401488 33 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0033273 response to vitamin GO Biological Processes -22.1296854 31 More
GO:0033280 response to vitamin D GO Biological Processes -11.9382575 14 More
GO:0034605 cellular response to heat GO Biological Processes -2.32243354 4 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034764 positive regulation of transmembrane transport GO Biological Processes -18.2616571 46 More
GO:0034765 regulation of ion transmembrane transport GO Biological Processes -18.4305966 71 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042056 chemoattractant activity GO Molecular Functions -15.3237868 13 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0042379 chemokine receptor binding GO Molecular Functions -11.1027858 13 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0045236 CXCR chemokine receptor binding GO Molecular Functions -7.10577702 6 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045661 regulation of myoblast differentiation GO Biological Processes -4.24103271 7 More
GO:0045662 negative regulation of myoblast differentiation GO Biological Processes -6.15988440 6 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0050918 positive chemotaxis GO Biological Processes -15.2518887 14 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050921 positive regulation of chemotaxis GO Biological Processes -35.4880405 36 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051279 regulation of release of sequestered calcium ion into cytosol GO Biological Processes -5.25087734 14 More
GO:0051282 regulation of sequestering of calcium ion GO Biological Processes -7.93009971 22 More
GO:0051607 defense response to virus GO Biological Processes -3.02916189 22 More
GO:0051924 regulation of calcium ion transport GO Biological Processes -18.2498286 49 More
GO:0051928 positive regulation of calcium ion transport GO Biological Processes -8.94961635 14 More
GO:0060142 regulation of syncytium formation by plasma membrane fusion GO Biological Processes -2.86749174 6 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0061061 muscle structure development GO Biological Processes -23.2569142 77 More
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide GO Biological Processes -7.52692728 10 More
GO:0070098 chemokine-mediated signaling pathway GO Biological Processes -11.4747808 14 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071621 granulocyte chemotaxis GO Biological Processes -16.4324548 18 More
GO:0071674 mononuclear cell migration GO Biological Processes -16.6998600 20 More
GO:0071675 regulation of mononuclear cell migration GO Biological Processes -19.9332328 23 More
GO:0071677 positive regulation of mononuclear cell migration GO Biological Processes -15.5919825 16 More
GO:0072678 T cell migration GO Biological Processes -4.46557398 5 More
GO:0090025 regulation of monocyte chemotaxis GO Biological Processes -10.2459261 9 More
GO:0090026 positive regulation of monocyte chemotaxis GO Biological Processes -11.8198427 9 More
GO:0097529 myeloid leukocyte migration GO Biological Processes -25.8454617 28 More
GO:0097530 granulocyte migration GO Biological Processes -19.1764933 21 More
GO:0098586 cellular response to virus GO Biological Processes -6.52248641 17 More
GO:0140546 defense response to symbiont GO Biological Processes -3.00647654 22 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1901343 negative regulation of vasculature development GO Biological Processes -32.5354692 52 More
GO:1901681 sulfur compound binding GO Molecular Functions -28.2504512 39 More
GO:1901739 regulation of myoblast fusion GO Biological Processes -3.76608029 6 More
GO:1903169 regulation of calcium ion transmembrane transport GO Biological Processes -8.80532519 28 More
GO:1904062 regulation of cation transmembrane transport GO Biological Processes -18.6629834 61 More
GO:1904427 positive regulation of calcium ion transmembrane transport GO Biological Processes -4.11465146 13 More
GO:1905330 regulation of morphogenesis of an epithelium GO Biological Processes -7.22524154 15 More
GO:1990266 neutrophil migration GO Biological Processes -18.6358512 20 More
GO:1990868 response to chemokine GO Biological Processes -10.9019396 14 More
GO:1990869 cellular response to chemokine GO Biological Processes -10.9019396 14 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000181 negative regulation of blood vessel morphogenesis GO Biological Processes -32.6997315 52 More
KEGG pathways: 10 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04061 Viral protein interaction with cytokine and cytokine receptor KEGG Pathway -30.3399237 29 More
hsa04062 Chemokine signaling pathway KEGG Pathway -9.12263704 17 More
hsa04620 Toll-like receptor signaling pathway KEGG Pathway -11.1460554 15 More
hsa04622 RIG-I-like receptor signaling pathway KEGG Pathway -3.50554828 6 More
hsa04623 Cytosolic DNA-sensing pathway KEGG Pathway -5.78243801 8 More
hsa04657 IL-17 signaling pathway KEGG Pathway -16.8039621 19 More
hsa04668 TNF signaling pathway KEGG Pathway -16.5384917 20 More
hsa05164 Influenza A KEGG Pathway -16.0885267 23 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
Drug-Gene interaction
view
Related drugs: 12 records
Drug name Interaction type Source PMID View
antibiotic NCI 10634213 view
atorvastatin NCI 10559511 view
atropine NCI 15315164 view
eldelumab TdgClinicalTrialTTD view
methylprednisolone NCI 17220550 view
ni-0801 inhibitor ChemblInteractionsTTD view
oxaliplatin NCI 16101140 view
regramostim NCI 11591765 view
ritonavir NCI 11141242 view
stavudine NCI 11141242 view
testosterone NCI 9681518 view
zidovudine NCI 11141242 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
C-X-C motif chemokine 10 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Koten K et al. Clin Biochem. 2008
All rights reserved: Soochow University Center for Systems Biology